Stability to heat
Sodium Ferrous Citrate (SFC), the ingredient of Sanferol®, is stable to heat up to approximately 270°C without decomposing. The melting point of SFC was determined as directed under the Melting Point Determination in the General Tests of the Japanese Pharmacopoeia; it decomposed and became brown and then to dark brown at approximately 270°C. Figure 2 shows the differential thermal analysis (DTA) data for SFC.1)
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Figure 2. Differential Thermal Analysis (DTA)
Temp. Rate: 5°C per minute
Sensitivity: 200 UV
Chart Speed: 5 mm per minute
Control: Black Cell (Al2O3)
Sample weight: About 2 mg
Cited from Ishino Y et al. (1988). Pharmaceutical Regulatory Science 19(1):44-52.
Reference:
- 1)
- Ishino Y, Takashima M, Terashima C, Orimo Y (1988). Physicochemical properties and stability of tetrasodium biscitrato iron (II). Pharmaceutical Regulatory Science 19(1):44-52 [English Translation].
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