High solubility
Sodium Ferrous Citrate (SFC), the ingredient of Sanferol®, readily dissolves in a wide range of pH values between 1 and 8. An amount of SFC, ferrous fumarate and ferrous sulfate was accurately weighted to correspond to 50 mg of iron. To each compound, 100 mL of a buffer solution at each pH was added. These solutions were then stirred at 37°C in a thermostat bath for 30 minutes and centrifuged. The amount of iron in the supernatant was measured using the Phenanthroline Visual Colorimetric Method.
As shown in Figure 1, nearly 100% of SFC was dissolved over the pH range of 1 to 8. Thus, it is evident that SFC dissolved readily at a wide range of acidic and basic pH values, whereas the solubility of ferrous fumarate and ferrous sulfate decreased at neutral to basic pH values.1)
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Figure 1. Solubility in each pH solution
pH1, 2, 4: Walpole buffer
pH5, 6: Michaelis buffer
pH8: Sorensen buffer
Cited from Ishino Y et al. (1988). Pharmaceutical Regulatory Science 19(1):44-52.
Reference:
- 1)
- Ishino Y, Takashima M, Terashima C, Orimo Y (1988). Physicochemical properties and stability of tetrasodium biscitrato iron (II). Pharmaceutical Regulatory Science 19(1):44-52 [English Translation].
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