Since it can be soluble in the form of chelated iron (non-ionic iron) even in weak basic pH conditions, Sodium Ferrous Citrate (SFC), the ingredient of Sanferol^®, releases fewer iron ions than other iron materials such as ferrous sulfate and ferrous fumarate. Thus, it irritates the gastric mucosa less than other iron materials. In addition, in practical treatment, it was reported that anemic pregnant patients who could not take ferrous sulfate due to gastrointestinal disorders were able to take SFC,¹²⁾ and that the number of patients who required dose reduction or treatment discontinuation was lower in the SFC group (6.5%) than in the ferrous sulfate group (9.5%). With respect to the occurrence of adverse reactions stratified by age, patients aged 50 years or above who took SFC had a significantly lower rate than those who took ferrous sulfate (U-test, p<0.05).²⁰⁾

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