Patients with hypoacidity
In general, an iron preparation orally administered first dissolves in the gastric acid of the stomach and is absorbed from the small intestine, mainly the duodenum. However, in patients who have undergone total gastrostomy, an iron preparation directly moves to the small intestine. Because the pH value of the small intestine is more basic than that of the stomach, the iron preparation is not likely to dissolve in the small intestine. Ferromia® (Sodium Ferrous Citrate, SFC) dissolves as a low molecular weight chelate in a broad acidic to basic pH range, and thus iron from SFC is well absorbed even in patients who have had a subtotal or total gastrectomy.17)-19) In contrast, a ferrous sulfate preparation poorly dissolves at basic pH, and the absorption of iron is decreased accordingly.
References:
- 17)
- Kariyazono H et al. (1993). Clinical research on iron absorption in patients who had gastrectomy. Surgical Metabolism and Nutrition 27(2): 107-112 [English summary].
- 18)
- Johno I et al. (1992). Clinical research on iron absorption in patients who had a total gastrectomy. Medical Consultation and New Remedies 29(5): 1235-1240 [English summary].
- 19)
- Hori M and Nishi M (1988). Therapeutic effects of oral administration of Ferromia® tablets in anemic patients after subtotal or total gastrectomy. Japanese J of Clinical and Experimental Medicine 65(9): 3033-3035 [English summary].
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